You need to sing it to the tune of the Prince song, Sexy MF. I would link to YouTube, but Prince threatened to sue anyone who posted even a parody of one of his songs, so there isn’t even a karaoke rendition to be seen or heard.
Homozygous MTHFR you ask? I’m glad I did, c’est for sure!
Last year I had a bunch of bloodwork done when we switched specialists, and one of the tests came back indicating that I have the Methylene Tetrahydrofolate Reductase gene mutation. Homozygous, meaning I have inherited two copies of the variant (heterozygous is inheriting only a single copy). MTHFR for short (go on, say it aloud!).
The implications of this, are that I have an increased risk of vascular disease, and possibly miscarriage. The MTHFR mutation is indicated in a lot of women who have had recurrent miscarriage. 5-15% of the population are homozygous for this gene mutation.
My sister, who is a midwife, was looking through my file notes ( I get copies of everything) and noticed the MTHFR result and asked me what my specialist had done about it. Most of her women with it are on high dose folate and baby aspirin at the least, and anti-coagulants such as clexane at the upper end. My Dr hadn’t even mentioned that I had the mutation!
So I brought it up yesterday at my appointment, which was actually with a different Dr. While giving me the usual non-committal “it’s not 100% proven” spiel, she made a few phone calls to see what other Drs had to say. The result is that I am now on 5mg of Folic Acid (ten times my previous dose) with further assessment if I do get pregnant. I don’t really have a family history of blood clots, and my homocysteine level was moderate, which is good.
Glad I brought it up!
So the good news, is that I am doing a Frozen Embryo Transfer (FET) THIS CYCLE!!!! I went in just to plan for the next cycle and she signed me up to do a FET right away. I am on CD11 right now, so transfer could be as early as next week. Excite!
I am doing a “natural” cycle which means I am doing daily urine tests to monitor the level of Lutenising Hormone (LH). A surge in LH indicates that ovulation is imminent. The embryo is then thawed and transferred a few days later. And hopefully two weeks after that, I get a positive pregnancy test!
The good thing about FETs is that she said I can do them all back-to-back if the cycles are unsuccessful. And if none of the four frozen embryos work, I should just scrape in another stimulated cycle before the end of the year. Pessimist, aren’t I? I just like to have plans and know what is going on.